Chalcones identify cTXNPx as a potential antileishmanial drug target.

• Main Authors: Douglas O Escrivani (Author), Rebecca L Charlton (Author), Marjolly B Caruso (Author), Gabriela A Burle-Caldas (Author), Maria Paula G Borsodi (Author), Russolina B Zingali (Author), Natalia Arruda-Costa (Author), Marcos V Palmeira-Mello (Author), Jéssica B de Jesus (Author), Alessandra M T Souza (Author), Bárbara Abrahim-Vieira (Author), Stefanie Freitag-Pohl (Author), Ehmke Pohl (Author), Paul W Denny (Author), Bartira Rossi-Bergmann (Author), Patrick G Steel (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

With current drug treatments failing due to toxicity, low efficacy and resistance; leishmaniasis is a major global health challenge that desperately needs new validated drug targets. Inspired by activity of the natural chalcone 2',6'-dihydroxy-4'-methoxychalcone (DMC), the nitro-analo...