Chalcones identify cTXNPx as a potential antileishmanial drug target.

• Автори: Douglas O Escrivani (Автор), Rebecca L Charlton (Автор), Marjolly B Caruso (Автор), Gabriela A Burle-Caldas (Автор), Maria Paula G Borsodi (Автор), Russolina B Zingali (Автор), Natalia Arruda-Costa (Автор), Marcos V Palmeira-Mello (Автор), Jéssica B de Jesus (Автор), Alessandra M T Souza (Автор), Bárbara Abrahim-Vieira (Автор), Stefanie Freitag-Pohl (Автор), Ehmke Pohl (Автор), Paul W Denny (Автор), Bartira Rossi-Bergmann (Автор), Patrick G Steel (Автор)
• Формат: Книга
• Опубліковано: Public Library of Science (PLoS), 2021-11-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

With current drug treatments failing due to toxicity, low efficacy and resistance; leishmaniasis is a major global health challenge that desperately needs new validated drug targets. Inspired by activity of the natural chalcone 2',6'-dihydroxy-4'-methoxychalcone (DMC), the nitro-analo...