Genetic interactions between planar cell polarity genes cause diverse neural tube defects in mice

• Main Authors: Jennifer N. Murdoch (Author), Christine Damrau (Author), Anju Paudyal (Author), Debora Bogani (Author), Sara Wells (Author), Nicholas D. E. Greene (Author), Philip Stanier (Author), Andrew J. Copp (Author)
• Format: Book
• Published: The Company of Biologists, 2014-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Neural tube defects (NTDs) are among the commonest and most severe forms of developmental defect, characterized by disruption of the early embryonic events of central nervous system formation. NTDs have long been known to exhibit a strong genetic dependence, yet the identity of the genetic determina...