Scientific and regulatory evaluation of mechanistic in silico drug and disease models in drug development: Building model credibility

• المؤلفون الرئيسيون: Flora T. Musuamba (مؤلف), Ine Skottheim Rusten (مؤلف), Raphaëlle Lesage (مؤلف), Giulia Russo (مؤلف), Roberta Bursi (مؤلف), Luca Emili (مؤلف), Gaby Wangorsch (مؤلف), Efthymios Manolis (مؤلف), Kristin E. Karlsson (مؤلف), Alexander Kulesza (مؤلف), Eulalie Courcelles (مؤلف), Jean‐Pierre Boissel (مؤلف), Cécile F. Rousseau (مؤلف), Emmanuelle M. Voisin (مؤلف), Rossana Alessandrello (مؤلف), Nuno Curado (مؤلف), Enrico Dall'ara (مؤلف), Blanca Rodriguez (مؤلف), Francesco Pappalardo (مؤلف), Liesbet Geris (مؤلف)
• التنسيق: كتاب
• منشور في: Wiley, 2021-08-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Abstract The value of in silico methods in drug development and evaluation has been demonstrated repeatedly and convincingly. While their benefits are now unanimously recognized, international standards for their evaluation, accepted by all stakeholders involved, are still to be established. In this...