High resolution melting curve analysis, a rapid and affordable method for mutation analysis in childhood acute myeloid leukemia

• Main Authors: Yin eLiu (Author), Jingyan eTang (Author), Peter eWakamatsu (Author), Huiliang eXue (Author), Jing eChen (Author), Paul S Gaynon (Author), Shuhong eShen (Author), Weili eSun (Author)
• Format: Book
• Published: Frontiers Media S.A., 2014-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Molecular genetic alterations with prognostic significance have been described in childhood acute myeloid leukemia (AML). The aim of this study was to establish cost-effective techniques to detect mutations of FMS-like tyrosine kinase 3 (FLT3), Nucleophosmin 1 (NPM1), and a partial tande...