Peroxiredoxin 2 Ameliorates AβO-Mediated Autophagy by Inhibiting ROS via the ROS-NRF2-p62 Pathway in N2a-APP Swedish Cells

• Hauptverfasser: Wei Jin (Verfasst von), Min Kyoung Kam (Verfasst von), Sung Woo Lee (Verfasst von), Young-Ho Park (Verfasst von), Hong Jun Lee (Verfasst von), Dong-Seok Lee (Verfasst von)
• Format: Buch
• Veröffentlicht: MDPI AG, 2022-09-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

In Alzheimer's disease, reactive oxygen species (ROS) are generated by the deposition of amyloid-beta oligomers (AβOs), which represent one of the important causes of neuronal cell death. Additionally, AβOs are known to induce autophagy via ROS induction. Previous studies have shown that autoph...