Peroxiredoxin 2 Ameliorates AβO-Mediated Autophagy by Inhibiting ROS via the ROS-NRF2-p62 Pathway in N2a-APP Swedish Cells

• Главные авторы: Wei Jin (Автор), Min Kyoung Kam (Автор), Sung Woo Lee (Автор), Young-Ho Park (Автор), Hong Jun Lee (Автор), Dong-Seok Lee (Автор)
• Формат: ‌
• Опубликовано: MDPI AG, 2022-09-01T00:00:00Z.
• Предметы: article
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In Alzheimer's disease, reactive oxygen species (ROS) are generated by the deposition of amyloid-beta oligomers (AβOs), which represent one of the important causes of neuronal cell death. Additionally, AβOs are known to induce autophagy via ROS induction. Previous studies have shown that autoph...