Synergy of novel coumarin derivatives and tamoxifen in blocking growth and inducing apoptosis of breast cancer cells

• Main Authors: Lulzime Ballazhi (Author), Faik Imeri (Author), Aleksandar Dimovski (Author), Ahmed Jashari (Author), Emil Popovski (Author), Pranvera Breznica-Selmani (Author), Bozhana Mikhova (Author), Gerald Dräger (Author), Edita Alili-Idrizi (Author), Kristina Mladenovska (Author)
• Format: Book
• Published: University Ss Cyril and Methodius in Skopje, Faculty of Pharmacy and Macedonian Pharmaceutical Association, 2014-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Possible synergistic effect of tamoxifen (2 μM) and hydrazinyldiene-chroman-2,4-diones (10-100 μM) was examined with an aim to create more effective treatment for ER+ breast cancer. Anti-breast cancer effect has been evaluated on the proliferation of MCF-7 breast adenocarcinoma cells using MTT and a...