Lack of Evidence for Involvement of P-Glycoprotein in Brain Uptake of the Centrally Acting Analgesic, Tramadol in the Rat

• Main Authors: Behjat Sheikholeslami (Author), Mehrdad Hamidi (Author), Hoda Lavasani (Author), Mohammad Sharifzadeh (Author), Mohammadreza Rouini (Author)
• Format: Book
• Published: Frontiers Media S.A., 2012-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose. Tramadol Hydrochloride is a widely-used centrally acting analgesic drug, which has some features of being a P-gp substrate. The present study evaluates the functional involvement of P-gp in CNS distribution of tramadol. Methods. The possibe involvement of P-glycoprotein in brain distributio...