Nonclinical immunogenicity risk assessment for knobs-into-holes bispecific IgG1 antibodies

• Main Authors: Wen-Ting K. Tsai (Author), Yinyin Li (Author), Zhaojun Yin (Author), Peter Tran (Author), Qui Phung (Author), Zhenru Zhou (Author), Kun Peng (Author), Dan Qin (Author), Sien Tam (Author), Christoph Spiess (Author), Jochen Brumm (Author), Manda Wong (Author), Zhengmao Ye (Author), Patrick Wu (Author), Sivan Cohen (Author), Paul J. Carter (Author)
• Format: Book
• Published: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Bispecific antibodies, including bispecific IgG, are emerging as an important new class of antibody therapeutics. As a result, we, as well as others, have developed engineering strategies designed to facilitate the efficient production of bispecific IgG for clinical development. For example, we have...