Oral delivery of bi-autoantigens by bacterium-like particles (BLPs) against autoimmune diabetes in NOD mice

• Autori principali: Ruifeng Mao (Autore), Jin Wang (Autore), Ying Xu (Autore), Yuqi Wang (Autore), Mengmeng Wu (Autore), Lixia Mao (Autore), Yingying Chen (Autore), Dengchao Li (Autore), Tong Zhang (Autore), Enjie Diao (Autore), Zhenjing Chi (Autore), Yefu Wang (Autore), Xin Chang (Autore)
• Natura: Libro
• Pubblicazione: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

AbstractInduction of oral tolerance by vaccination with type 1 diabetes mellitus (T1DM)-associated autoantigens exhibits great potential in preventing and treating this autoimmune disease. However, antigen degradation in the gastrointestinal tract (GIT) limits the delivery efficiency of oral antigen...