Oral delivery of bi-autoantigens by bacterium-like particles (BLPs) against autoimmune diabetes in NOD mice

• Main Authors: Ruifeng Mao (Author), Jin Wang (Author), Ying Xu (Author), Yuqi Wang (Author), Mengmeng Wu (Author), Lixia Mao (Author), Yingying Chen (Author), Dengchao Li (Author), Tong Zhang (Author), Enjie Diao (Author), Zhenjing Chi (Author), Yefu Wang (Author), Xin Chang (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

AbstractInduction of oral tolerance by vaccination with type 1 diabetes mellitus (T1DM)-associated autoantigens exhibits great potential in preventing and treating this autoimmune disease. However, antigen degradation in the gastrointestinal tract (GIT) limits the delivery efficiency of oral antigen...