The upregulated intestinal folate transporters direct the uptake of ligand-modified nanoparticles for enhanced oral insulin delivery

• Main Authors: Jingyi Li (Author), Yaqi Zhang (Author), Miaorong Yu (Author), Aohua Wang (Author), Yu Qiu (Author), Weiwei Fan (Author), Lars Hovgaard (Author), Mingshi Yang (Author), Yiming Li (Author), Rui Wang (Author), Xiuying Li (Author), Yong Gan (Author)
• Format: Book
• Published: Elsevier, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Transporters are traditionally considered to transport small molecules rather than large-sized nanoparticles due to their small pores. In this study, we demonstrate that the upregulated intestinal transporter (PCFT), which reaches a maximum of 12.3-fold expression in the intestinal epithelial cells...