Soluble Egg Antigens of Schistosoma japonicum Induce Senescence of Activated Hepatic Stellate Cells by Activation of the FoxO3a/SKP2/P27 Pathway.

• প্রধান লেখক: Yinong Duan (লেখক), Jing Pan (লেখক), Jinling Chen (লেখক), Dandan Zhu (লেখক), Jianxin Wang (লেখক), Xiaolei Sun (লেখক), Liuting Chen (লেখক), Liting Wu (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Public Library of Science (PLoS), 2016-12-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

BACKGROUND:Liver fibrosis was viewed as a reversible process. The activation of hepatic stellate cells (HSCs) is a key event in the process of liver fibrosis. The induction of senescence of HSCs would accelerate the clearance of the activated HSCs. Previously, we demonstrated that soluble egg antige...