Saxagliptin Attenuates Albuminuria by Inhibiting Podocyte Epithelial- to-Mesenchymal Transition via SDF-1α in Diabetic Nephropathy

• Main Authors: Yun-peng Chang (Author), Bei Sun (Author), Zhe Han (Author), Fei Han (Author), Shao-lan Hu (Author), Xiao-yu Li (Author), Mei Xue (Author), Yang Yang (Author), Li Chen (Author), Chun-jun Li (Author), Li-ming Chen (Author)
• Format: Book
• Published: Frontiers Media S.A., 2017-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The dipeptidyl peptidase-4 (DPP-4) inhibitor saxagliptin has been found to reduce progressive albuminuria, but the exact mechanism of inhibition is unclear. Podocyte epithelial-to-mesenchymal transition (EMT) has emerged as a potential pathway leading to proteinuria in diabetic nephropathy (DN). Str...