Dipeptide Repeat Pathology in <i>C9orf72</i>-ALS Is Associated with Redox, Mitochondrial and NRF2 Pathway Imbalance

• Main Authors: José Jiménez-Villegas (Author), Janine Kirby (Author), Ana Mata (Author), Susana Cadenas (Author), Martin R. Turner (Author), Andrea Malaspina (Author), Pamela J. Shaw (Author), Antonio Cuadrado (Author), Ana I. Rojo (Author)
• Format: Book
• Published: MDPI AG, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The hexanucleotide expansion of the <i>C9orf72</i> gene is found in 40% of familial amyotrophic lateral sclerosis (ALS) patients. This genetic alteration has been connected with impaired management of reactive oxygen species. In this study, we conducted targeted transcriptional profiling...