P2X7 Receptor Expression in Patients With Serositis Related to Systemic Lupus Erythematosus

• Main Authors: Federica Furini (Author), Anna Lisa Giuliani (Author), Mattia Erminio Parlati (Author), Marcello Govoni (Author), Francesco Di Virgilio (Author), Alessandra Bortoluzzi (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: P2X7R is an extracellular ATP-gated receptor involved in inflammatory and autoimmune processes mainly acting through NLPR3-inflammasome activation and IL-1β release, also implicated in lymphocyte proliferation and cellular apoptosis. Several observations from animal models and patients...