Advanced Research on Dopamine Signaling to Develop Drugs for the Treatment of Mental Disorders: Biochemical and Behavioral Profiles of Phosphodiesterase Inhibition in Dopaminergic Neurotransmission

• 主要な著者: Akinori Nishi (著者), Gretchen L. Snyder (著者)
• フォーマット: 図書
• 出版事項: Elsevier, 2010-01-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Dopamine plays a central role in the regulation of psychomotor functions. The effect of dopamine is largely mediated through the cAMP/PKA signaling cascade and therefore controlled by phosphodiesterases (PDEs). Multiple PDEs with different substrate specificities and subcellular localization are exp...