In Vitro and In Vivo Modulation of Alternative Splicing by the Biguanide Metformin

• Main Authors: Delphine Laustriat (Author), Jacqueline Gide (Author), Laetitia Barrault (Author), Emilie Chautard (Author), Clara Benoit (Author), Didier Auboeuf (Author), Anne Boland (Author), Christophe Battail (Author), François Artiguenave (Author), Jean-François Deleuze (Author), Paule Bénit (Author), Pierre Rustin (Author), Sylvia Franc (Author), Guillaume Charpentier (Author), Denis Furling (Author), Guillaume Bassez (Author), Xavier Nissan (Author), Cécile Martinat (Author), Marc Peschanski (Author), Sandrine Baghdoyan (Author)
• Format: Book
• Published: Elsevier, 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Major physiological changes are governed by alternative splicing of RNA, and its misregulation may lead to specific diseases. With the use of a genome-wide approach, we show here that this splicing step can be modified by medication and demonstrate the effects of the biguanide metformin, on alternat...