Synthesis, biological evaluation and molecular modeling studies on novel quinonoid inhibitors of CDC25 phosphatases

• Main Authors: Emilie Evain-Bana (Author), Lucie Schiavo (Author), Christophe Bour (Author), Don Antoine Lanfranchi (Author), Simone Berardozzi (Author), Francesca Ghirga (Author), Denyse Bagrel (Author), Bruno Botta (Author), Gilles Hanquet (Author), Mattia Mori (Author)
• Format: Book
• Published: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The cell division cycle 25 phosphatases (CDC25A, B, and C; E.C. 3.1.3.48) are key regulator of the cell cycle in human cells. Their aberrant expression has been associated with the insurgence and development of various types of cancer, and with a poor clinical prognosis. Therefore, CDC25 phosphatase...