Salubrinal improves mechanical properties of the femur in osteogenesis imperfecta mice

• Main Authors: Shinya Takigawa (Author), Brian Frondorf (Author), Shengzhi Liu (Author), Yang Liu (Author), Baiyan Li (Author), Akihiro Sudo (Author), Joseph M. Wallace (Author), Hiroki Yokota (Author), Kazunori Hamamura (Author)
• Format: Book
• Published: Elsevier, 2016-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Salubrinal is an agent that reduces the stress to the endoplasmic reticulum by inhibiting de-phosphorylation of eukaryotic translation initiation factor 2 alpha (eIF2α). We and others have previously shown that the elevated phosphorylation of eIF2α stimulates bone formation and attenuates bone resor...