Supplemental Ascorbate Diminishes DNA Damage Yet Depletes Glutathione and Increases Acute Liver Failure in a Mouse Model of Hepatic Antioxidant System Disruption

Cellular oxidants are primarily managed by the thioredoxin reductase-1 (TrxR1)- and glutathione reductase (Gsr)-driven antioxidant systems. In mice having hepatocyte-specific co-disruption of TrxR1 and Gsr (TrxR1/Gsr-null livers), methionine catabolism sustains hepatic levels of reduced glutathione...

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Main Authors: Colin G. Miller (Author), Jean A. Kundert (Author), Justin R. Prigge (Author), Julie A. Amato (Author), Allison E. Perez (Author), Lucia Coppo (Author), Gabrielle N. Rizzo (Author), Michael P. Kavanaugh (Author), David J. Orlicky (Author), Colin T. Shearn (Author), Edward E. Schmidt (Author)
Format: Book
Published: MDPI AG, 2021-02-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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