Supplemental Ascorbate Diminishes DNA Damage Yet Depletes Glutathione and Increases Acute Liver Failure in a Mouse Model of Hepatic Antioxidant System Disruption

• Main Authors: Colin G. Miller (Author), Jean A. Kundert (Author), Justin R. Prigge (Author), Julie A. Amato (Author), Allison E. Perez (Author), Lucia Coppo (Author), Gabrielle N. Rizzo (Author), Michael P. Kavanaugh (Author), David J. Orlicky (Author), Colin T. Shearn (Author), Edward E. Schmidt (Author)
• Format: Book
• Published: MDPI AG, 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cellular oxidants are primarily managed by the thioredoxin reductase-1 (TrxR1)- and glutathione reductase (Gsr)-driven antioxidant systems. In mice having hepatocyte-specific co-disruption of TrxR1 and Gsr (TrxR1/Gsr-null livers), methionine catabolism sustains hepatic levels of reduced glutathione...