Overexpression of ST5, an activator of Ras, has no effect on β-cell proliferation in adult mice

• Main Authors: Kristy Ou (Author), Jia Zhang (Author), Yang Jiao (Author), Zhao V. Wang (Author), Phillipp Scherer (Author), Klaus H. Kaestner (Author)
• Format: Book
• Published: Elsevier, 2018-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Both Type I and Type II diabetes mellitus result from insufficient functional β-cell mass. Efforts to increase β-cell proliferation as a means to restore β-cell mass have been met with limited success. Suppression of Tumorigenicity 5 (ST5) activates Ras/Erk signaling in the presence of Ep...