Sustained antiviral response against in vitro HIV-1 infection in peripheral blood mononuclear cells from people with chronic myeloid leukemia treated with ponatinib

• Main Authors: Mario Manzanares (Author), Fernando Ramos-Martín (Author), Sara Rodríguez-Mora (Author), Guiomar Casado-Fernández (Author), Clara Sánchez-Menéndez (Author), Alicia Simón-Rueda (Author), Elena Mateos (Author), Miguel Cervero (Author), Adam M. Spivak (Author), Vicente Planelles (Author), Montserrat Torres (Author), Valentín García-Gutiérrez (Author), Mayte Coiras (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

HIV-1 infection cannot be cured due to long-lived viral reservoirs formed by latently infected CD4+ T cells. "Shock and Kill" strategy has been considered to eliminate the viral reservoir and achieve a functional cure but the stimulation of cytotoxic immunity is necessary. Ponatinib is a t...