Sustained antiviral response against in vitro HIV-1 infection in peripheral blood mononuclear cells from people with chronic myeloid leukemia treated with ponatinib

• Auteurs principaux: Mario Manzanares (Auteur), Fernando Ramos-Martín (Auteur), Sara Rodríguez-Mora (Auteur), Guiomar Casado-Fernández (Auteur), Clara Sánchez-Menéndez (Auteur), Alicia Simón-Rueda (Auteur), Elena Mateos (Auteur), Miguel Cervero (Auteur), Adam M. Spivak (Auteur), Vicente Planelles (Auteur), Montserrat Torres (Auteur), Valentín García-Gutiérrez (Auteur), Mayte Coiras (Auteur)
• Format: Livre
• Publié: Frontiers Media S.A., 2024-09-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

HIV-1 infection cannot be cured due to long-lived viral reservoirs formed by latently infected CD4+ T cells. "Shock and Kill" strategy has been considered to eliminate the viral reservoir and achieve a functional cure but the stimulation of cytotoxic immunity is necessary. Ponatinib is a t...