New 1,2,4-oxadiazole derivatives with positive mGlu4 receptor modulation activity and antipsychotic-like properties

• Main Authors: Anna Stankiewicz (Author), Katarzyna Kaczorowska (Author), Ryszard Bugno (Author), Aneta Kozioł (Author), Maria H. Paluchowska (Author), Grzegorz Burnat (Author), Barbara Chruścicka (Author), Paulina Chorobik (Author), Piotr Brański (Author), Joanna M. Wierońska (Author), Beata Duszyńska (Author), Andrzej Pilc (Author), Andrzej J. Bojarski (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Considering the allosteric regulation of mGlu receptors for potential therapeutic applications, we developed a group of 1,2,4-oxadiazole derivatives that displayed mGlu4 receptor positive allosteric modulatory activity (EC50 = 282-656 nM). Selectivity screening revealed that they were devoid of acti...