Development and Evaluation of a Quantitative Systems Pharmacology Model for Mechanism Interpretation and Efficacy Prediction of Atezolizumab in Combination with Carboplatin and Nab-Paclitaxel in Patients with Non-Small-Cell Lung Cancer

• Главные авторы: Chen-Yu Wang (Автор), Hao-Ran Dai (Автор), Yu-Ping Tan (Автор), Di-Hong Yang (Автор), Xiao-Min Niu (Автор), Lu Han (Автор), Wen Wang (Автор), Ling-Ling Ma (Автор), Aleksi Julku (Автор), Zheng Jiao (Автор)
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• Опубликовано: MDPI AG, 2024-02-01T00:00:00Z.
• Предметы: article
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Immunotherapy has shown clinical benefit in patients with non-small-cell lung cancer (NSCLC). Due to the limited response of monotherapy, combining immune checkpoint inhibitors (ICIs) and chemotherapy is considered a treatment option for advanced NSCLC. However, the mechanism of combined therapy and...