Development and Evaluation of a Quantitative Systems Pharmacology Model for Mechanism Interpretation and Efficacy Prediction of Atezolizumab in Combination with Carboplatin and Nab-Paclitaxel in Patients with Non-Small-Cell Lung Cancer

• Main Authors: Chen-Yu Wang (Author), Hao-Ran Dai (Author), Yu-Ping Tan (Author), Di-Hong Yang (Author), Xiao-Min Niu (Author), Lu Han (Author), Wen Wang (Author), Ling-Ling Ma (Author), Aleksi Julku (Author), Zheng Jiao (Author)
• Format: Book
• Published: MDPI AG, 2024-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Immunotherapy has shown clinical benefit in patients with non-small-cell lung cancer (NSCLC). Due to the limited response of monotherapy, combining immune checkpoint inhibitors (ICIs) and chemotherapy is considered a treatment option for advanced NSCLC. However, the mechanism of combined therapy and...