Selective M3 Muscarinic Receptor Antagonist Inhibits Small-Cell Lung Carcinoma Growth in a Mouse Orthotopic Xenograft Model

Selective M3 Muscarinic Receptor Antagonist Inhibits Small-Cell Lung Carcinoma Growth in a Mouse Orthotopic Xenograft Model

Abstract.: In small cell lung carcinoma (SCLC), acetylcholine (ACh) is synthesized and secreted, and it acts as an autocrine growth factor through activation of its receptors, muscarinic receptor (mAChR) and nicotinic receptor (nAChR). Alteration of tumor growth by blockade of M3 mAChR in a human SC...

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Main Authors: Nozomi Ami (Author), Kazumi Koga (Author), Hiroshi Fushiki (Author), Yoko Ueno (Author), Yoshio Ogino (Author), Hisashi Ohta (Author)
Format: Book
Published: Elsevier, 2011-01-01T00:00:00Z.
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3rd Floor Main Library

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