miR-379 mediates insulin resistance and obesity through impaired angiogenesis and adipogenesis regulated by ER stress

• Main Authors: Maryam Abdollahi (Author), Mitsuo Kato (Author), Linda Lanting (Author), Ragadeepthi Tunduguru (Author), Mei Wang (Author), Yangmeng Wang (Author), Patrick T. Fueger (Author), Qiong Wang (Author), Wendong Huang (Author), Rama Natarajan (Author)
• Format: Book
• Published: Elsevier, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We investigated the role of microRNA (miR-379) in the pathogenesis of obesity, adipose tissue dysfunction, and insulin resistance (IR). We used miR-379 knockout (miR-379KO) mice to test whether loss of miR-379 affects high-fat diet (HFD)-induced obesity and IR via dysregulation of key miR-379 target...