Inhibitory Effects of Isoliquiritigenin and Licorice Extract on Voltage-Dependent K+ Currents in H9c2 Cells

• Main Authors: Chisato Noguchi (Author), Jing Yang (Author), Kazuho Sakamoto (Author), Ryo Maeda (Author), Kenji Takahashi (Author), Hiroshi Takasugi (Author), Tomoyuki Ono (Author), Masahiro Murakawa (Author), Junko Kimura (Author)
• Format: Book
• Published: Elsevier, 2008-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The effect of isoliquiritigenin (ISL), a component of licorice, on the voltage-dependent, ultra-rapidly activating delayed-rectifier K+ current (IKur) was examined in H9c2 cells, a cell-line derived from rat cardiac myoblasts. IKur was recorded using the whole-cell patch clamp method with a pipette...