Non-Functional Trace Amine-Associated Receptor 1 Variants in Patients With Mental Disorders

• Main Authors: Grazia Rutigliano (Author), Julia Bräunig (Author), Claudia Del Grande (Author), Vittoria Carnicelli (Author), Isabella Masci (Author), Sergio Merlino (Author), Gunnar Kleinau (Author), Luca Tessieri (Author), Simone Pardossi (Author), Sarah Paisdzior (Author), Liliana Dell'Osso (Author), Heike Biebermann (Author), Riccardo Zucchi (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: The G protein-coupled receptor (GPCR) trace amine-associated receptor 1 (TAAR1) is expressed across brain areas involved in emotions, reward and cognition, and modulates monoaminergic and glutamatergic neurotransmissions. TAAR1 is stimulated with nanomolar affinity by 3-iodothyronamine (...