Extensive Thiol Profiling for Assessment of Intracellular Redox Status in Cultured Cells by HPLC-MS/MS

• Main Authors: Jiandong Wu (Author), Anna Chernatynskaya (Author), Annalise Pfaff (Author), Huari Kou (Author), Nan Cen (Author), Nuran Ercal (Author), Honglan Shi (Author)
• Format: Book
• Published: MDPI AG, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Oxidative stress may contribute to the pathology of many diseases, and endogenous thiols, especially glutathione (GSH) and its metabolites, play essential roles in the maintenance of normal redox status. Understanding how these metabolites change in response to oxidative insult can provide key insig...