SYK promotes the formation of neutrophil extracellular traps by inducing PKM2 nuclear translocation and promoting STAT3 phosphorylation to exacerbate hepatic ischemia-reperfusion injury and tumor recurrence

• Main Authors: Xuejiao Chen (Author), Chuanwei Jiang (Author), Minhao Chen (Author), Xiangdong Li (Author), Wenjie Yu (Author), Aigang Qiu (Author), Linfeng Sun (Author), Liyong Pu (Author), Yuhua Shi (Author)
• Format: Book
• Published: BMC, 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background At present, hepatic ischemia-reperfusion injury (IRI) is an important complication of partial hepatectomy and liver transplantation, and it is an important cause of poor prognosis. Spleen tyrosine kinase(SYK) plays an important role in a variety of signaling pathways in the liver...