Aging Exacerbates Ischemia-Reperfusion-Induced Mitochondrial Respiration Impairment in Skeletal Muscle

• Main Authors: Stéphanie Paradis (Author), Anne-Laure Charles (Author), Isabelle Georg (Author), Fabienne Goupilleau (Author), Alain Meyer (Author), Michel Kindo (Author), Gilles Laverny (Author), Daniel Metzger (Author), Bernard Geny (Author)
• Format: Book
• Published: MDPI AG, 2019-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cycles of ischemia-reperfusion (IR) that occur during peripheral arterial disease (PAD) are associated with significant morbi-mortality, and aging is an irreversible risk factor of PAD. However, the effects of advanced age on IR-induced skeletal muscle mitochondrial dysfunction are not well known. Y...