Exacerbation of Intracranial Aneurysm and Aortic Dissection in Hypertensive Rat Treated With the Prostaglandin F-Receptor Antagonist AS604872

• Main Authors: Miyuki Fukuda (Author), Tomohiro Aoki (Author), Toshiaki Manabe (Author), Akiko Maekawa (Author), Takayuki Shirakawa (Author), Hiroharu Kataoka (Author), Yasushi Takagi (Author), Susumu Miyamoto (Author), Shuh Narumiya (Author)
• Format: Book
• Published: Elsevier, 2014-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract.: Intracranial aneurysm (IA) and aortic dissection are both complications of hypertension and characterized by degeneration of the media. Given the involvement of prostaglandin F2α and its receptor, FP, in extracellular matrix remodeling in a mouse model of pulmonary fibrosis, here we induc...