Dermal open flow microperfusion for PK-based clinical bioequivalence studies of topical drug products

• Autors principals: Thomas Birngruber (Autor), Katrin I. Tiffner (Autor), Selma I. Mautner (Autor), Frank M. Sinner (Autor)
• Format: Llibre
• Publicat: Frontiers Media S.A., 2022-11-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

Topically applied drug products have experienced an extraordinary price increase in the United States, mostly due to a lack of generic products. Generic drug development is hindered by high costs and risks associated with clinical endpoint studies required to show bioequivalence (BE) of prospective...