Histone methyltransferase MLL4 protects against pressure overload-induced heart failure via a THBS4-mediated protection in ER stress

• Main Authors: Xiang-Min Meng (Author), Qiu-Yu Pang (Author), Zhen-Fang Zhou (Author), Jing-Han Yuan (Author), Lu You (Author), Qi-Pu Feng (Author), Bing-Mei Zhu (Author)
• Format: Book
• Published: Elsevier, 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pressure overload-induced pathological cardiac hypertrophy eventually leads to heart failure (HF). Unfortunately, lack of effective targeted therapies for HF remains a challenge in clinical management. Mixed-lineage leukemia 4 (MLL4) is a member of the SET family of histone methyltransferase enzymes...