Formulation Development of Solid Self-Nanoemulsifying Drug Delivery Systems of Quetiapine Fumarate via Hot-Melt Extrusion Technology: Optimization Using Central Composite Design

• Main Authors: Prateek Uttreja (Author), Ahmed Adel Ali Youssef (Author), Indrajeet Karnik (Author), Kavish Sanil (Author), Nagarjuna Narala (Author), Honghe Wang (Author), Rasha M. Elkanayati (Author), Sateesh Kumar Vemula (Author), Michael A. Repka (Author)
• Format: Book
• Published: MDPI AG, 2024-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Quetiapine fumarate (QTF) was approved for the treatment of schizophrenia and acute manic episodes. QTF can also be used as an adjunctive treatment for major depressive disorders. QTF oral bioavailability is limited due to its poor aqueous solubility and pre-systemic metabolism. The objective of the...