O-Acetylation is essential for functional antibody generation against Staphylococcus aureus capsular polysaccharide

• Main Authors: Ingrid L. Scully (Author), Viliam Pavliak (Author), Yekaterina Timofeyeva (Author), Yongdong Liu (Author), Christine Singer (Author), Annaliesa S. Anderson (Author)
• Format: Book
• Published: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Staphylococcus aureus produces an antiphagocytic polysaccharide capsule to evade neutrophil-mediated killing. Many vaccines against encapsulated bacterial pathogens require generation of functional anti-capsular antibodies to mediate protection against infection and disease. Here it is shown that th...