Formulation, stability testing, and analytical characterization of melatonin-based preparation for clinical trial

• Main Authors: Samira Filali (Author), Charlotte Bergamelli (Author), Mamadou Lamine Tall (Author), Damien Salmon (Author), Diane Laleye (Author), Carole Dhelens (Author), Elhadji Diouf (Author), Christine Pivot (Author), Fabrice Pirot (Author)
• Format: Book
• Published: Elsevier, 2017-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A new institutional clinical trial assessed the improvement of sleep disorders in 40 children with autism treated by immediate-release melatonin formulation in different regimens (0.5 mg, 2 mg, and 6 mg daily) for one month. The objectives of present study were to (i) prepare low-dose melatonin hard...