Effect of repeated oral administration of chondroitin sulfate on neuropathic pain induced by partial sciatic nerve ligation in mice

• Egile Nagusiak: Wataru Nemoto (Egilea), Kotaro Yamada (Egilea), Osamu Nakagawasai (Egilea), Yoshiki Ogata (Egilea), Masato Chiba (Egilea), Ryota Yamagata (Egilea), Hidetomo Sakurai (Egilea), Koichi Tan-No (Egilea)
• Formatua: Liburua
• Argitaratua: Elsevier, 2018-08-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

We examined whether chondroitin sulfate (CS), a compound used to treat osteoarthritis and joint pain, is effective against partial sciatic nerve ligation (PSNL)-induced neuropathic pain. Repeated oral administration of CS (300 mg/kg, b.i.d. for 20 days) resulted in inhibition of tactile allodynia ob...