Effect of repeated oral administration of chondroitin sulfate on neuropathic pain induced by partial sciatic nerve ligation in mice

• Main Authors: Wataru Nemoto (Author), Kotaro Yamada (Author), Osamu Nakagawasai (Author), Yoshiki Ogata (Author), Masato Chiba (Author), Ryota Yamagata (Author), Hidetomo Sakurai (Author), Koichi Tan-No (Author)
• Format: Book
• Published: Elsevier, 2018-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We examined whether chondroitin sulfate (CS), a compound used to treat osteoarthritis and joint pain, is effective against partial sciatic nerve ligation (PSNL)-induced neuropathic pain. Repeated oral administration of CS (300 mg/kg, b.i.d. for 20 days) resulted in inhibition of tactile allodynia ob...