Effect of repeated oral administration of chondroitin sulfate on neuropathic pain induced by partial sciatic nerve ligation in mice

• Auteurs principaux: Wataru Nemoto (Auteur), Kotaro Yamada (Auteur), Osamu Nakagawasai (Auteur), Yoshiki Ogata (Auteur), Masato Chiba (Auteur), Ryota Yamagata (Auteur), Hidetomo Sakurai (Auteur), Koichi Tan-No (Auteur)
• Format: Livre
• Publié: Elsevier, 2018-08-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

We examined whether chondroitin sulfate (CS), a compound used to treat osteoarthritis and joint pain, is effective against partial sciatic nerve ligation (PSNL)-induced neuropathic pain. Repeated oral administration of CS (300 mg/kg, b.i.d. for 20 days) resulted in inhibition of tactile allodynia ob...