Effect of repeated oral administration of chondroitin sulfate on neuropathic pain induced by partial sciatic nerve ligation in mice

• Autori principali: Wataru Nemoto (Autore), Kotaro Yamada (Autore), Osamu Nakagawasai (Autore), Yoshiki Ogata (Autore), Masato Chiba (Autore), Ryota Yamagata (Autore), Hidetomo Sakurai (Autore), Koichi Tan-No (Autore)
• Natura: Libro
• Pubblicazione: Elsevier, 2018-08-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

We examined whether chondroitin sulfate (CS), a compound used to treat osteoarthritis and joint pain, is effective against partial sciatic nerve ligation (PSNL)-induced neuropathic pain. Repeated oral administration of CS (300 mg/kg, b.i.d. for 20 days) resulted in inhibition of tactile allodynia ob...