Effect of repeated oral administration of chondroitin sulfate on neuropathic pain induced by partial sciatic nerve ligation in mice

• Váldodahkkit: Wataru Nemoto (Dahkki), Kotaro Yamada (Dahkki), Osamu Nakagawasai (Dahkki), Yoshiki Ogata (Dahkki), Masato Chiba (Dahkki), Ryota Yamagata (Dahkki), Hidetomo Sakurai (Dahkki), Koichi Tan-No (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Elsevier, 2018-08-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

We examined whether chondroitin sulfate (CS), a compound used to treat osteoarthritis and joint pain, is effective against partial sciatic nerve ligation (PSNL)-induced neuropathic pain. Repeated oral administration of CS (300 mg/kg, b.i.d. for 20 days) resulted in inhibition of tactile allodynia ob...