Effect of repeated oral administration of chondroitin sulfate on neuropathic pain induced by partial sciatic nerve ligation in mice

• Автори: Wataru Nemoto (Автор), Kotaro Yamada (Автор), Osamu Nakagawasai (Автор), Yoshiki Ogata (Автор), Masato Chiba (Автор), Ryota Yamagata (Автор), Hidetomo Sakurai (Автор), Koichi Tan-No (Автор)
• Формат: Книга
• Опубліковано: Elsevier, 2018-08-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

We examined whether chondroitin sulfate (CS), a compound used to treat osteoarthritis and joint pain, is effective against partial sciatic nerve ligation (PSNL)-induced neuropathic pain. Repeated oral administration of CS (300 mg/kg, b.i.d. for 20 days) resulted in inhibition of tactile allodynia ob...