IMPACT OF NLRP3 INFLAMMASOME ON THE DEVELOPMENT OF HYPERTENSION AND RENAL AND CARDIAC HYPERTROPHY IN 2K1C AND DOCA/SALT MICE

• Autors principals: Q. Wang (Autor), A So (Autor), J. Nussberger (Autor), J. Tschopp (Autor), M. Burnier (Autor)
• Format: Llibre
• Publicat: The Korean Society of Nephrology, 2012-06-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

NLRP3 inflammasome is formed by NLRP3, the adaptor ASC, and caspase-1, functions as a sensor of danger signals and triggers processing and release of interleukin-1beta (IL-1β). Recent animal studies demonstrate that NLRP3 inflammasome promotes renal inflammation. However, little is known on the role...