Cardiomyocyte Triglyceride Accumulation and Reduced Ventricular Function in Mice with Obesity Reflect Increased Long Chain Fatty Acid Uptake and De Novo Fatty Acid Synthesis

• Main Authors: Fengxia Ge (Author), Chunguang Hu (Author), Eiichi Hyodo (Author), Kotaro Arai (Author), Shengli Zhou (Author), Harrison Lobdell IV (Author), José L. Walewski (Author), Shunichi Homma (Author), Paul D. Berk (Author)
• Format: Book
• Published: Hindawi Limited, 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A nonarteriosclerotic cardiomyopathy is increasingly seen in obese patients. Seeking a rodent model, we studied cardiac histology, function, cardiomyocyte fatty acid uptake, and transporter gene expression in male C57BL/6J control mice and three obesity groups: similar mice fed a high-fat diet (HFD)...