Brazilin from Caesalpinia sappan L. as a Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibitor: Pharmacophore-Based Virtual Screening, In Silico Molecular Docking, and In Vitro Studies

Brazilin from Caesalpinia sappan L. as a Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibitor: Pharmacophore-Based Virtual Screening, In Silico Molecular Docking, and In Vitro Studies

Background. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a crucial regulator of low-density lipoprotein cholesterol (LDL-c) levels, as it binds to and degrades the LDL receptor (LDLR) in the lysosome of hepatocytes. Elevated levels of PCSK9 have been linked to an increased LDL-c plasma l...

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Main Authors: Muhammad Iqbal (Author), Nur Hasanah (Author), Aimee Detria Arianto (Author), Widya Dwi Aryati (Author), Meidi Utami Puteri (Author), Fadlina Chany Saputri (Author)
Format: Book
Published: Hindawi Limited, 2023-01-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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