FITM2 deficiency results in ER lipid accumulation, ER stress, and reduced apolipoprotein B lipidation and VLDL triglyceride secretion in vitro and in mouse liver

• Main Authors: Haizhen Wang (Author), Cyrus Nikain (Author), Konstantinos I. Fortounas (Author), Jaume Amengual (Author), Ozlem Tufanli (Author), Maxwell La Forest (Author), Yong Yu (Author), Meng C. Wang (Author), Russell Watts (Author), Richard Lehner (Author), Yunping Qiu (Author), Min Cai (Author), Irwin J. Kurland (Author), Ira J. Goldberg (Author), Sujith Rajan (Author), M. Mahmood Hussain (Author), Jeffrey L. Brodsky (Author), Edward A. Fisher (Author)
• Format: Book
• Published: Elsevier, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Triglycerides (TGs) associate with apolipoprotein B100 (apoB100) to form very low density lipoproteins (VLDLs) in the liver. The repertoire of factors that facilitate this association is incompletely understood. FITM2, an integral endoplasmic reticulum (ER) protein, was originally discove...