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FITM2 deficiency results in ER lipid accumulation, ER stress, and reduced apolipoprotein B lipidation and VLDL triglyceride secretion in vitro and in mouse liver

Objective: Triglycerides (TGs) associate with apolipoprotein B100 (apoB100) to form very low density lipoproteins (VLDLs) in the liver. The repertoire of factors that facilitate this association is incompletely understood. FITM2, an integral endoplasmic reticulum (ER) protein, was originally discove...

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Main Authors: Haizhen Wang (Author), Cyrus Nikain (Author), Konstantinos I. Fortounas (Author), Jaume Amengual (Author), Ozlem Tufanli (Author), Maxwell La Forest (Author), Yong Yu (Author), Meng C. Wang (Author), Russell Watts (Author), Richard Lehner (Author), Yunping Qiu (Author), Min Cai (Author), Irwin J. Kurland (Author), Ira J. Goldberg (Author), Sujith Rajan (Author), M. Mahmood Hussain (Author), Jeffrey L. Brodsky (Author), Edward A. Fisher (Author)
Format: Book
Published: Elsevier, 2024-12-01T00:00:00Z.
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