Age-specific breast and ovarian cancer risks associated with germline BRCA1 or BRCA2 pathogenic variants - an Asian study of 572 familiesResearch in context

• Main Authors: Weang-Kee Ho (Author), Nur Tiara Hassan (Author), Sook-Yee Yoon (Author), Xin Yang (Author), Joanna M.C. Lim (Author), Nur Diana Binte Ishak (Author), Peh Joo Ho (Author), Eldarina A. Wijaya (Author), Patsy Pei-Sze Ng (Author), Craig Luccarini (Author), Jamie Allen (Author), Mei-Chee Tai (Author), Jianbang Chiang (Author), Zewen Zhang (Author), Mee-Hoong See (Author), Meow-Keong Thong (Author), Yin-Ling Woo (Author), Alison M. Dunning (Author), Mikael Hartman (Author), Cheng-Har Yip (Author), Nur Aishah Mohd Taib (Author), Douglas F. Easton (Author), Jingmei Li (Author), Joanne Ngeow (Author), Antonis C. Antoniou (Author), Soo-Hwang Teo (Author)
• Format: Book
• Published: Elsevier, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary: Background: Clinical management of Asian BRCA1 and BRCA2 pathogenic variants (PV) carriers remains challenging due to imprecise age-specific breast (BC) and ovarian cancer (OC) risks estimates. We aimed to refine these estimates using six multi-ethnic studies in Asia. Methods: Data were col...