Iron Overload, Oxidative Stress and Calcium Mishandling in Cardiomyocytes: Role of the Mitochondrial Permeability Transition Pore

• मुख्य लेखकों: Richard Gordan (लेखक), Nadezhda Fefelova (लेखक), Judith K. Gwathmey (लेखक), Lai-Hua Xie (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2020-08-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Iron (Fe) plays an essential role in many physiological processes. Hereditary hemochromatosis or frequent blood transfusions often cause iron overload (IO), which can lead to cardiomyopathy and arrhythmias; however, the underlying mechanism is not well defined. In the present study, we assess the hy...