Iron Overload, Oxidative Stress and Calcium Mishandling in Cardiomyocytes: Role of the Mitochondrial Permeability Transition Pore

• Autori principali: Richard Gordan (Autore), Nadezhda Fefelova (Autore), Judith K. Gwathmey (Autore), Lai-Hua Xie (Autore)
• Natura: Libro
• Pubblicazione: MDPI AG, 2020-08-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Iron (Fe) plays an essential role in many physiological processes. Hereditary hemochromatosis or frequent blood transfusions often cause iron overload (IO), which can lead to cardiomyopathy and arrhythmias; however, the underlying mechanism is not well defined. In the present study, we assess the hy...