Polymorphism of Drug Transporters, Rather Than Metabolizing Enzymes, Conditions the Pharmacokinetics of Rasagiline

• Main Authors: Pablo Zubiaur (Author), Miriam Matas (Author), Samuel Martín-Vílchez (Author), Paula Soria-Chacartegui (Author), Gonzalo Villapalos-García (Author), Laura Figueiredo-Tor (Author), Sofía Calleja (Author), Marcos Navares-Gómez (Author), Alejandro de Miguel (Author), Jesús Novalbos (Author), Gina Mejía-Abril (Author), Sergio Luquero-Bueno (Author), Manuel Román (Author), Dolores Ochoa (Author), Francisco Abad-Santos (Author)
• Format: Book
• Published: MDPI AG, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Rasagiline is a selective and irreversible inhibitor of monoamine oxidase type B with neuroprotective effect, indicated for the management of Parkinson's disease. The aim of this work was to evaluate the impact of seven <i>CYP1A2</i> alleles and of 120 additional variants located in...