PI3K p85α/HIF-1α accelerates the development of pulmonary arterial hypertension by regulating fatty acid uptake and mitophagy

• 主要な著者: Chenyang Chen (著者), Sirun Qin (著者), Xiaohua Song (著者), Juan Wen (著者), Wei Huang (著者), Zhe Sheng (著者), Xiaogang Li (著者), Yu Cao (著者)
• フォーマット: 図書
• 出版事項: BMC, 2024-11-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Abstract Background Pulmonary arterial hypertension (PAH) is characterized by lipid accumulation and mitochondrial dysfunction. This study was designed to investigate the effects of hypoxia-inducible factor-1α (HIF-1α) on fatty acid uptake and mitophagy in PAH. Methods Peripheral blood samples were...